Porzingis, the NBA’s second-leading scorer entering play Wednesday, has led the Knicks to six wins in their past seven games.
The 22-year-old is averaging 30 points per game and has established the Knicks franchise record for most total points through 10 games.
The Knicks are playing the second game of a back-to-back, which likely contributed to the team’s decision to keep Porzingis from playing in Orlando.
Porzingis’ absence will create a significant void for New York (6-4) on Wednesday.
The 7-3 forward is off to a blistering start, having scored at least 30 points in seven of 10 games. He’s shooting 51 percent from the field (38 percent from beyond the arc) and averaging 2.3 blocks and 7.5 rebounds per game. It was unclear who will start in place of Porzingis.
Mindaugas Kuzminskas was added to the active roster for the first time this season after Porzingis was ruled out.
ESPN’s Ian Begley contributed to this report.